Biochemical Hyperthyroidism in a Newborn Baby Caused by Assay Interaction from Biotin Intake

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False biochemical diagnosis of hyperthyroidism in streptavidin-biotin-based immunoassays: the problem of biotin intake and related interferences.

Immunoassays are now commonly used for hormone measurement, in high throughput analytical platforms. Immunoassays are generally robust to interference. However, endogenous analytical error may occur in some patients; this may be encountered in biotin supplementation or in the presence of anti-streptavidin antibody, in immunoassays involving streptavidin-biotin interaction. In these cases, the i...

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ژورنال

عنوان ژورنال: European Thyroid Journal

سال: 2016

ISSN: 2235-0640,2235-0802

DOI: 10.1159/000448034